Right now I'm just brainstorming ideas for crossovers, S.U.E. bullshit, hostile/disruptive entities in the Meta, and things which by their presence make reality go wonky.
That tends to get interesting scenarios, though Scan reality distortion -> Orbital fire on reality distortion -> repeat solves far too many of them, and there are also many where there isn't a clear answer to "What should we do here?", even with full information.
It's challenging to make decent antagonists. They're magnets for orbital fire, they need realistic goals and flaws, and they also need to have worked on their goals (within the bounds of their flaws) to the point where they are both powerful enough to be threatening, but weak enough to be defeated. The players also need a reason to go up against them, rather than ignore them or ally with them.
Such is the problem when you make a game. There is always the "Fastest path straight into bullshit" and players are DAMN good at finding it.