On a roll of 02
Every open orifice of the crew will gradually heal over. This means the mouth, eyes, ears, nose, anus, urethra, vagina, and even the sweat pores. The problems caused by this can only be solved by physically cutting the orifice open again, to allow the crew to eat, defecate, urinate and even breath. Any wounds quickly heal over as well, so the crew must cut every hour or so, or they will simply suffocate.
The next level of the problem causes all flesh to heal together. Fingers and toes join together, legs bind to each other, arms bind to the torso, until the body of the crewmember is like a fleshy slug. The problem can only be solved by more self-mutilitation.
Every day this goes on, roll a D6. On the first day, you must roll a one to have the problem disappear, on the second day you must roll under 2, and so on. On any day a roll of 6 will make the problem go to the next level. When the problem finally resolves, the crew still suffer the wounds they had to cause to relieve thier condition.