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The human body is a machine of flesh.
Trying to graft or implant it with mechanical bits, while interesting would be a terrible idea. Allow me to explain why:
Maintenance. Tell me, anyone here, have you even scraped your knee? Notice how that heals?
Welp, machines don't do that naturally. There's wear and tear all the damn time with our bodies, and you'd need to take something apart, find and fix the problem and then re-assemble. Now, the common man, as we understand him is not capable of this. Nor will he be for a very long time.
Then there is an issue of redundancy. What happens when you've got something that's become obsolete? Do you undergo expensive surgery to replace it?
The only way we'd be able to modify ourselves is with bio-engineering. Or nanites. Both in the *very* distant future.
As to what makes us human? The intrinsic properties of being an primate of our specific species. Nothing all that exciting or worth frothing at the mouth about, considering that it's our capacity for thought that sets us apart from many animals.
If souls exist, humour me here, supposedly if these things exist, then it shouldn't matter what bits you've replaced or how you live, it should be an intrinsic part of you. If you claim otherwise, then when does one stop having a soul? Is it stored somewhere in specific, like the pancreas?
tl;dr Mechanic grafts are a bad idea, biology ftw, loss of humanity lol, no, doesn't happen.